Thursday, September 1, 2016

Cancer Vaccines

Vaccines to help prevent cancer

Most of us know about vaccines given to healthy people to help prevent infections, such as measles and chicken pox. These vaccines use weakened or killed germs like viruses or bacteria to start an immune response in the body. Getting the immune system ready to defend against these germs helps keep people from getting infections.
Most cancer vaccines work the same way, but they make the person’s immune system attack cancer cells. The goal is to help treat cancer or to help keep it from coming back after other treatments. But there are also some vaccines that may actually help prevent certain cancers.
Many people might not realize it, but some cancers are caused by viruses. Vaccines that help protect against infections with these viruses might also help prevent some of these cancers.

To read more about this go to :http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/immunotherapy-cancer-vaccines 

Wednesday, July 27, 2016

Eating To Cure Cancer

I have been hearing a lot about this new diet, which is really and old diet, that might be helpful in curing cancer.  Now don't get me wrong I don't believe that there is only one way to cure or treat cancer, but a varied approach can't hurt.  I have a niece currently on this diet and it seems to be helping.  So I put it out here for your review.  To read more of the article go to Ketogenic Diet.

By Dr. Mercola
To some, a ketogenic diet amounts to nothing less than a drug-free cancer treatment. The diet calls for eliminating carbohydrates, replacing them with healthy fats and protein. 
The premise is that since cancer cells need glucose to thrive, and carbohydrates turn into glucose in your body, then cutting out carbs literally starves the cancer cells. 
This type of diet, in which you replace carbs with moderate amounts of high quality protein and high amounts of beneficial fat, is what I recommend for everyone, whether you have cancer or not. It's simply a diet that will help optimize your weight and health overall, as eating this way will help you convert from carb burning mode to fat burning.

Thursday, July 21, 2016

Cancer Fighting Foods/Spices

Locate more information at The Cancer Cure Foundation
The National Cancer Institute estimates that roughly one-third of all cancer deaths may be diet related. What you eat can hurt you, but it can also help you. Many of the common foods found in grocery stores or organic markets contain cancer-fighting properties, from the antioxidants that neutralize the damage caused by free radicals to the powerful phytochemicals that scientists are just beginning to explore. There isn't a single element in a particular food that does all the work: The best thing to do is eat a variety of foods.
The following foods have the ability to help stave off cancer and some can even help inhibit cancer cell growth or reduce tumor size.
Avocados are rich in glutathione, a powerful antioxidant that attacks free radicals in the body by blocking intestinal absorption of certain fats. They also supply even more potassium than bananas and are a strong source of beta-carotene. Scientists also believe that avocados may also be useful in treating viral hepatitis (a cause of liver cancer), as well as other sources of liver damage.
Broccoli, cabbage, and cauliflower have a chemical component called indole-3-carbinol that can combat breast cancer by converting a cancer-promoting estrogen into a more protective variety. Broccoli, especially sprouts, also have the phytochemical sulforaphane, a product of glucoraphanin - believed to aid in preventing some types of cancer, like colon and rectal cancer. Sulforaphane induces the production of certain enzymes that can deactivate free radicals and carcinogens. The enzymes have been shown to inhibit the growth of tumors in laboratory animals. However, be aware that the Agriculture Department studied 71 types of broccoli plants and found a 30-fold difference in the amounts of glucoraphanin. It appears that the more bitter the broccoli is, the more glucoraphanin it has. Broccoli sprouts have been developed under the trade name BroccoSprouts that have a consistent level of sulforaphane - as much as 20 times higher than the levels found in mature heads of broccoli.
Carrots contain a lot of beta carotene, which may help reduce a wide range of cancers including lung, mouth, throat, stomach, intestine, bladder, prostate and breast. Some research indicated beta carotene may actually cause cancer, but this has not proven that eating carrots, unless in very large quantities - 2 to 3 kilos a day, can cause cancer. In fact, a substance called falcarinol that is found in carrots has been found to reduce the risk of cancer, according to researchers at Danish Institute of Agricultural Sciences (DIAS). Kirsten Brandt, head of the research department, explained that isolated cancer cells grow more slowly when exposed to falcarinol. This substance is a polyacethylen, however, so it is important not to cook the carrots.
Chili peppers and jalapenos contain a chemical, capsaicin, which may neutralize certain cancer-causing substances (nitrosamines) and may help prevent cancers such as stomach cancer.
Cruciferous vegetables - broccoli, cauliflower, kale, Brussels sprouts, and cabbage contain two antioxidants, lutein and zeaxanthin that may help decrease prostate and other cancers.
Figs apparently have a derivative of benzaldehyde. It has been reported that investigators at the Institute of Physical and Chemical Research in Tokyo say benzaldehyde is highly effective at shrinking tumors, though I haven't seen this report. In addition, the U.S. Department of Agriculture says figs, which contain vitamins A and C, and calcium, magnesium and potassium, may curtail appetite and improve weight-loss efforts. Fig juice is also a potent bacteria killer in test-tube studies.
Flax contains lignans, which may have an antioxidant effect and block or suppress cancerous changes. Flax is also high in omega-3 fatty acids, which are thought to protect against colon cancer and heart disease. See Budwig diet for a specialized diet using flax seed oil and cottage cheese. For studies about flax seed and flax oil, go to our Important News or Archives Page.
Garlic has immune-enhancing allium compounds (dialyl sultides) that appear to increase the activity of immune cells that fight cancer and indirectly help break down cancer causing substances. These substances also help block carcinogens from entering cells and slow tumor development. Diallyl sulfide, a component of garlic oil, has also been shown to render carcinogens in the liver inactive. Studies have linked garlic — as well as onions, leeks, and chives — to lower risk of stomach and colon cancer. Dr. Lenore Arab, professor of epidemiology and nutrition at the UNC-CH (University of North Carolina at Chapel Hill) schools of public health and medicine and colleagues analyzed a number of studies and reported their findings in the October 2000 issue of the American Journal of Clinical Nutrition. According to the report, people who consume raw or cooked garlic regularly face about half the risk of stomach cancer and two-thirds the risk of colorectal cancer as people who eat little or none. Their studies didn't show garlic supplements had the same effect. It is believed garlic may help prevent stomach cancer because it has anti-bacterial effects against a bacterium, Helicobacter pylori, found in the stomach and known to promote cancer there.
Grapefruits, like oranges and other citrus fruits, contain monoterpenes, believed to help prevent cancer by sweeping carcinogens out of the body. Some studies show that grapefruit may inhibit the proliferation of breast-cancer cells in vitro. They also contains vitamin C, beta-carotene, and folic acid.
Grapes, red contain bioflavonoids, powerful antioxidants that work as cancer preventives. Grapes are also a rich source of resveratrol, which inhibits the enzymes that can stimulate cancer-cell growth and suppress immune response. They also contain ellagic acid, a compound that blocks enzymes that are necessary for cancer cells - this appears to help slow the growth of tumors.
Studies show that consumption of green and yellow leafy vegetables has been associated with lower levels of stomach cancer.
Kale has indoles, nitrogen compounds which may help stop the conversion of certain lesions to cancerous cells in estrogen-sensitive tissues. In addition, isothiocyanates, phytochemicals found in kale, are thought to suppress tumor growth and block cancer-causing substances from reaching their targets.
Licorice root has a chemical, glycyrrhizin, that blocks a component of testosterone and therefore may help prevent the growth of prostate cancer. However, excessive amounts can lead to elevated blood pressure.
Mushrooms - There are a number of mushrooms that appear to help the body fight cancer and build the immune system - Shiitake, maitake, reishi, Agaricus blazei Murill, and Coriolus Versicolor. These mushrooms contain polysaccharides, especially Lentinan, powerful compounds that help in building immunity. They are a source of Beta Glucan. They also have a protein called lectin, which attacks cancerous cells and prevents them from multiplying. They also contain Thioproline. These mushrooms can stimulate the production of interferon in the body.
Extracts from mushrooms have been successfully tested in recent years in Japan as an adjunct to chemotherapy. PSK is made from the Coriolus Versicolor. Maitake mushroom extract is PCM4.
Nuts contain the antioxidants quercetin and campferol that may suppress the growth of cancers. Brazil nut contains 80 micrograms of selenium, which is important for those with prostate cancer. (Note: Many people are allergic to the proteins in nuts, so if you have any symptoms such as itchy mouth, tight throat, wheezing, etc. after eating nuts, stop. Consider taking a selenium supplement instead or work with someone on how to eliminate this allergy.)
Oranges and lemons contain Iimonene which stimulates cancer-killing immune cells (lymphocytes, e.g.) that may also break down cancer-causing substances.
Papayas have vitamin C that works as an antioxidant and may also reduce absorption of cancer-causing nitrosamines from the soil or processed foods. Papaya contains folacin (also known as folic acid), which has been shown to minimize cervical dysplasia and certain cancers.
Raspberries contain many vitamins, minerals, plant compounds and antioxidants known as anthocyanins that may protect against cancer. According to a recent research study reported by Cancer Research 2001;61:6112-6119, rats fed diets of 5% to 10% black raspberries saw the number of esophageal tumors decrease by 43% to 62%. A diet containing 5% black raspberries was more effective than a diet containing 10% black raspberries. Research reported in the journal Nutrition and Cancer in May 2002 shows black raspberries may also thwart colon cancer. Black raspberries are rich in antioxidants, thought to have even more cancer-preventing properties than blueberries and strawberries.
Red wine, even without alcohol, has polyphenols that may protect against various types of cancer. Polyphenols are potent antioxidants, compounds that help neutralize disease-causing free radicals. Also, researchers at the University of North Carolina's medical school in Chapel Hill found the compound resveratrol, which is found in grape skins. It appears that resveratrol inhibits cell proliferation and can help prevent cancer. However, the findings didn't extend to heavy imbibers, so it should be used in moderation. In addition, alcohol can be toxic to the liver and to the nervous system, and many wines have sulfites, which may be harmful to your health. Note: some research indicates that alcohol is considered a class "A" carcinogen which can actually cause cancer - see http://www.jrussellshealth.com/alccanc.html. You should probably switch to non-alcoholic wines.
Rosemary may help increase the activity of detoxification enzymes. An extract of rosemary, termed carnosol, has inhibited the development of both breast and skin tumors in animals. We haven't found any studies done on humans. Rosemary can be used as a seasoning. It can also be consumed as a tea: Use 1 tsp. dried leaves per cup of hot water; steep for 15 minutes.
Seaweed and other sea vegetables contain beta-carotene, protein, vitamin B12, fiber, and chlorophyll, as well as chlorophylones - important fatty acids that may help in the fight against breast cancer. Many sea vegetables also have high concentrations of the minerals potassium, calcium, magnesium, iron, and iodine.
Soy products like tofu contain several types of phytoestrogens — weak, nonsteroidal estrogens that could help prevent both breast and prostate cancer by blocking and suppressing cancerous changes. There are a number of isoflavones in soy products, but research has shown that genistein is the most potent inhibitor of the growth and spread of cancerous cells. It appears to lower breast-cancer risk by inhibiting the growth of epithelial cells and new blood vessels that tumors require to flourish and is being scrutinized as a potential anti-cancer drug. However, there are some precautions to consider when adding soy to your diet. Eating up to 4 or 5 ounces of tofu or other soy a day is probably ok, but research is being done to see if loading up on soy could cause hormone imbalances that stimulate cancer growth. As a precaution, women who have breast cancer or are at high risk should talk to their doctors before taking pure isoflavone powder and pills, extracted from soy.
Sweet potatoes contain many anticancer properties, including beta-carotene, which may protect DNA in the cell nucleus from cancer-causing chemicals outside the nuclear membrane.
Teas: Green Tea and Black tea contain certain antioxidants known as polyphenols (catechins) which appear to prevent cancer cells from dividing. Green tea is best, followed by our more common black tea (herbal teas do not show this benefit). According to a report in the July 2001 issue of the Journal of Cellular Biochemistry, these polyphenols that are abundant in green tea, red wine and olive oil, may protect against various types of cancer. Dry green tea leaves, which are about 40% polyphenols by weight, may also reduce the risk of cancer of the stomach, lung, colon, rectum, liver and pancreas, study findings have suggested.
Tapioca is derived from the cassava plant. It is one of the many plants that manufactures cyanide by producing a chemical called linamarine which releases hydrogen cyanide when it is broken down by the linamarase enzyme. Spanish researches have been studying the cassava and attempting to clone the genes from the plant which are responsible for producing the hydrogen cyanide and then transfer it to a retrovirus. However, funding for the project has run out. http://news.bbc.co.uk/hi/english/health/newsid_317000/317467.stmfor more information on this. For a list of other foods that contain B17, go to our laetrile page.
Tomatoes contain lycopene, an antioxidant that attacks roaming oxygen molecules, known as free radicals, that are suspected of triggering cancer. It appears that the hotter the weather, the more lycopene tomatoes produce. They also have vitamin C, an antioxidant which can prevent cellular damage that leads to cancer. Watermelons, carrots, and red peppers also contain these substances, but in lesser quantities. It is concentrated by cooking tomatoes. Scientists in Israel have shown that lycopene can kill mouth cancer cells. An increased intake of lycopene has already been linked to a reduced risk of breast, prostate, pancreas and colorectal cancer. (Note: Recent studies indicate that for proper absorption, the body also needs some oil along with lycopene.)
Tumeric (curcuma longa), a member of the ginger family, is believed to have medicinal properties because it inhibits production of the inflammation-related enzyme cyclo-oxygenase 2 (COX-2), levels of which are abnormally high in certain inflammatory diseases and cancers, especially bowel and colon cancer. In fact, a pharmaceutical company Phytopharm in the UK hopes to introduce a natural product, P54, that contains certain volatile oils, which greatly increase the potency of the turmeric spice.
Turnips are said to contain glucose molaes which is a cancer fighting compound. I haven't confirmed this.
Consumption of fruits and vegetables has been associated with decreased risk of cancers of the colon and rectum.
There are many good books on this topic, including Vern Verona's book on "Cancer Fighting Foods."

Monday, July 18, 2016

Cancer, sea life, mental health and Brexit

An interesting article to read from the Guardian after the Brexit issue.  Here is just a bit:

Loss of funding seems inevitable, a “worrisome” development, as Ramakrishnan describes it. “Unfortunately, there are even more worrying things in the pipeline,” he says. Consider the networks and contacts that the UK has established with our European counterparts over the decades. Science is a highly collaborative process and thrives on interactions. These could easily evaporate if Britain is no longer involved in EU research projects as a full partner.
“For a start, we learn a great deal from these interactions,” says cancer expert Professor Mark Lawler, of Queen’s University Belfast. “Take the example of early cancer diagnosis. That is something that the UK has been poor at in the past. However, with recent collaborations, particularly with Denmark, we have been learning how to improve them. Now this process is threatened.
“In addition, there is our ability to direct science policy and projects. We have been closely involved at the very beginning of major projects – such as those emanating from the EU’s vast Horizon 2020 research programme. We have played a key leadership role in setting them up, selecting personnel and establishing the direction of research.”
An example is provided by research in precision medicine, which uses the recently acquired ability to study individual variability in genes, environment and lifestyle to create new medicines and treatments for cancer patients. A European precision medicine programme is now being set up – initially with the UK playing a key role. “It remains to be seen what our role will be now,” adds Lawler.
For the complete article go to: Brexit/Education/The Guardian

Tuesday, April 26, 2016

Stem Cells and Cancer

small minority of patients treated with a common chemotherapy drug develop severe heart damage, but there is currently no way of identifying in advance who they might be. Now, researchers have developed a method using reprogrammed stem cells derived from the patient's own skin cells that predicts whether they fall into this group.
Heart anatomy
Around 8% of patients treated with the chemotherapy drug doxorubicin develop cardiotoxicity, where the heart muscles become damaged.
The chemotherapy drug doxorubicin (brand name Adriamycin) is very effective against a wide range of cancers - including breast cancer and childhood leukemia. But in around 8% of patients, it causes cardiotoxicity, where the heart muscles become damaged, and in severe cases, leads to heart failure.
Writing in the journal Nature Medicine, researchers from Stanford University, Stanford, CA, and Northwestern University, Chicago, IL, explain how they developed the stem celltechnique and then went on to discover the likely genetic reasons for the differences in reaction to the drug.
In theory, it should be possible to take some of the patient's heart cells, grow them in the lab and then test the drug on them. But, in practice, it is very difficult to isolate heart cells from patients and grow them in the lab.
Therefore, the team decided to try another route. Other studies have already reported successfully using readily available skin cells from the patient to make stem cells and then coax them into becoming the desired cell type.
For their study, the researchers took skin cells from breast cancer patients who had been treated with doxorubicin - including some with cardiotoxicity.
They reprogrammed the skin cells so they regressed to a precursor state called induced pluripotent stem cells - stem cells with the potential to differentiate into many different cell types.
The researchers then coaxed the stem cells to become heart muscle cells, treated them with doxorubicin and measured their reactions.

Results could lead to a DNA test for likelihood of cardiotoxicity

Lead author Paul Burridge, assistant professor of pharmacology at Northwestern, explains what they found:
"Our results showed that heart cells from patients who have cardiotoxicity were significantly more sensitive to doxorubicin-induced toxicity. They had more structural damage, reduced contraction, DNA damage and died more easily."
Finally, after identifying genetic differences behind the drug responses, the researchers suggest the toxic side effect might be the result of mitochondrial dysfunction. Mitochondria are tiny compartments inside cells that produce the chemical energy they need to function.
The study has obvious implications for the treatment of cancer patients. It could lead to a DNA test that finds out if a patient is likely to develop cardiotoxicity if treated with doxorubicin, Prof. Burridge suggests, and adds:
"This patient could then be given an alternative chemotherapy drug or a lower dose. In contrast, patients who are likely to be resistant to doxorubicin-induced cardiotoxicity might be able to be given a higher dose and have a better chance of success with their chemotherapy."
Meanwhile, Medical News Today recently learned how researchers have succeeded in making retinal ganglion cells from stem cells derived from patients' skins cells in a bid toward personalized treatments for glaucoma.

Sunday, April 24, 2016

Survival Increases Chances of Death From Something Else

Breast cancer survivors, particularly older women, are at greater risk of death from non-cancer causes than from breast cancer.
As breast cancer treatments improve, patients are surviving longer, and many are dying of causes unrelated to breast cancer. Judith-Anne Chapman, Ph.D., and colleagues with the National Cancer Institute of Canada Clinical Trials Group investigated whether certain factors, such as pre-existing diseases, are associated with the risk of death from breast cancer, other cancers, or causes other than cancer. For about four years, the researchers followed over 5,000 women enrolled in a breast cancer trial.
During the follow-up, 256 participants died. Non-breast cancer deaths were more common than deaths from breast cancer, and older women, in particular, were more likely to die of other causes. While 60 percent of women in the trial died of causes not related to breast cancer, this figure jumped to 72 percent among women 70 years and older. Two factors were associated with cause of death. Women with pre-existing heart disease were more likely to die of non-cancer causes, and women with pre-existing osteoporosis were at greater risk of dying from cancers other than breast cancer. Women were more likely to die from breast cancer if cancer cells had spread to the lymph nodes.
"Routine use of screening mammography and improved therapeutic management of breast cancer...will mean that more women will survive breast cancer to older ages, at which they might have a higher risk of death from causes other than breast cancer," the authors write.
In an accompanying editorial, Sharon Giordano, M.D., and Gabriel Hortobagyi, M.D., of the University of Texas M. D. Anderson Cancer Center in Houston discuss the need for oncologists to consider a patient's pre-existing health problems when determining treatment options.
For example, "cardiovascular disease is of particular concern to breast cancer patients because of its prevalence and the reality that many therapies for breast cancer can cause cardiac dysfunction," the editorialists write.

Story Source:
The above post is reprinted from materials provided by Journal of the National Cancer InstituteNote: Materials may be edited for content and length.

Cite This Page:
Journal of the National Cancer Institute. "Non-Cancer Deaths More Common Among Breast Cancer Survivors." ScienceDaily. ScienceDaily, 15 February 2008. .